Twin Study: The Relationship Between Food Allergies and Gut Microbiota (Part 2)

Through 16S rRNA gene amplicon sequencing of fecal samples from 13 healthy individuals and 23 food-allergic individuals (including 18 pairs of twins), it was found that the main bacterial families in the feces were Lachnospiraceae and Ruminococcaceae, which is consistent with previously reported research results. For each pair of twins, the relative abundance of operational taxonomic units (OTUs) was compared, representing the microbiomes between closely related individuals, while the OTU correlation within each pair of twins was calculated. There was no significant difference in OTU correlation between discordant twins and concordant twins or between monozygotic and dizygotic twin pairs. In other words, the relative abundance of the microbiome composition in healthy and allergic twins showed no difference at the family level.

Figure 1 Relative abundance of the microbiome composition in twins

Figure caption: Figure (A) shows the taxonomic relative abundance at the family level. Sample IDs are displayed on the x-axis (n = 34). Discordant twins (12 pairs, n = 24), where one member is healthy and the other is allergic. Concordant twins (5 pairs, n = 10), where both members are allergic.

Figure B shows the comparison between concordant and discordant twins. Figure C shows the comparison between monozygotic and dizygotic twins. Each point represents one pair of twins (showing 17 pairs). Each point represents one sample. Figures D and E show the Shannon α diversity index between the healthy group and the allergic group, with all samples displayed in D (n = 34) and only discordant twins displayed in E (n = 24). Each point represents one sample.

Figure 2 Heatmap of the microbial distribution in twins

Figure 3 Intrauterine differences in the biological composition of twins
This experiment compared the microbial composition between allergic twins and healthy twins, identifying 64 OTUs that were differentially abundant between the two groups, with 62 OTUs being abundant in healthy twins, the vast majority of which were primarily from the genus Clostridium (marked in pink on the left side of the image), accounting for about 84%. The allergic twins had 2 abundant OTUs. Among all samples, the OTU scores of healthy twins were significantly higher than those of allergic twins, due to differences in the relative abundance scores of discordant twins, where most of the differentially abundant OTUs were present in healthy twins and absent in allergic twins. The experiment indicates that the fecal microbiome characteristics of healthy twins and allergic twins have significant differences.
References: Fecal microbiome and metabolome differ in healthy and food-allergic twins
Note: This article is for informational purposes only and is not intended as medical guidance.

Relationships, twins, allergies, health, otu, differences, relatively, rich

The microbial regulation of short-chain fatty acids by postbiotics on human physiological health.

Twin Study: The Relationship Between Food Allergies and Gut Microbiota (Part 1)

The microbial regulation of short-chain fatty acids by postbiotics on human physiological health.

Twin Study: The Relationship Between Food Allergies and Gut Microbiota (Part 1)

2024-12-23

In December 2024, Tianjin Chuangyuan Biotechnology Co., Ltd. and Haihe Dairy jointly held a series of themed activities titled "Party Building Mutual Visits and Learning" to further promote the deep integration of both parties' party building work and business development. During the event, both sides will conduct company visits and on-site discussions. Recently, Haihe Dairy made an initial visit and, after gaining a deep understanding of Chuangyuan Biotech's products, expressed high recognition and close attention, laying a solid foundation for future cooperation. Subsequently, both parties engaged in detailed communication on the core topics of "exchange of party building experiences and sharing of business resources," discussing standardized construction of party branches, distinctive party building measures, and the promotion of party-business integration. They also conducted in-depth exchanges on aspects such as corporate cooperation, product intercommunication, and information sharing, jointly exploring new paths for the development of the health industry under the guidance of party building, providing more possibilities for further establishing a "symbiotic, mutually promoting, and win-win" cooperative relationship. Both parties hope to achieve industrial resonance through party building leadership and contribute to the development of the health industry in the Binhai New Area.

Strength crowned, Chuangyuan Biotechnology won two Science and Technology Awards from the China Food Industry Association.

2024-12-17

On December 16, 2024, the 22nd China Food Safety Conference and the 2024 National Food Industry Science and Technology Progress Conference, themed "Implementing Food Safety Strategy to Support the Construction of a Healthy China," was grandly held in Beijing. During the conference, the award ceremony for the 2024 National Food Industry Science and Technology Progress Conference was also held. Tianjin Chuangyuan Biotechnology Co., Ltd. won the second prize for scientific and technological progress in the "2023 China Food Industry Association Science and Technology Award" for two projects: "Key Technology Breakthrough and Industrial Application of New Postbiotics Segmented Solid-State Fermentation" and "Development and Application of Key Technologies and Equipment for Plant Polysaccharide Efficacy Verification and Extraction."

Chuangyuan Biotech's lactic acid bacteria IOB701 post-fermentation probiotic powder has been granted a national invention patent.

2024-12-13

On December 13, 2024, Tianjin Chuangyuan Biotechnology Co., Ltd. received an invention patent certificate from the National Intellectual Property Administration for its independently developed and filed method and application for the preparation of Lactobacillus plantarum IOB701 fermented postbiotics powder (Patent No.: ZL 202411354886.X). This invention provides a method and application for the preparation of Lactobacillus plantarum IOB701 fermented postbiotics powder, which relates to the field of microbiology. The Lactobacillus plantarum IOB701 was preserved on July 10, 2018, at the General Microbial Culture Collection Center of the China Microbial Strain Preservation Management Committee, abbreviated as CGMCC, with the preservation address at No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number CGMCC No. 16077. Using grains or legumes treated with low oxygen stress as the fermentation substrate, the Lactobacillus plantarum IOB701 fermentation resulted in postbiotics powder, which, according to animal experiments, has been shown to improve chronic unpredictable mild stress-induced depressive-like behavior in mice.

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