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Research on the correlation between whole grain intake and liver cancer, chronic hepatitis.
Whole grains contain components such as endosperm, bran, and germ. Whole grains are a valuable food source of dietary fiber, vitamins B, E, selenium, zinc, copper, magnesium, and phytochemicals. For a long time, whole grains and dietary fiber have been considered beneficial in reducing the risk of type 2 diabetes, cardiovascular diseases, and certain types of cancer. The intake of whole grains has potential beneficial effects on non-alcoholic fatty liver disease. A recent systematic review indicates that whole grain intake has a protective effect against the occurrence and development of liver cancer. So far, two prospective studies have reported a negative correlation between dietary fiber intake and the risk of liver cancer, with one study indicating a negative correlation between whole grain intake and liver cancer incidence.
Whole grains are a good source of dietary fiber, resistant starch, and oligosaccharides, which can increase stool bulk, accelerate intestinal transit, and reduce exposure to carcinogens in the colon. Grains contain antioxidants and phytoestrogens, which have been reported to have protective effects in certain gastrointestinal cancers and hormone-sensitive cancers. Dietary fiber has been reported to have beneficial effects on liver disease and liver cancer-related conditions (including blood sugar), insulin sensitivity, liver fat content, and metabolic syndrome. Oligosaccharides, as fermentable carbohydrates, ferment in the colon and increase the production of short-chain fatty acids, which are important for maintaining intestinal integrity and regulating inflammation.
Recent studies have found that the effects of dietary fiber may be mediated by changes in the gut microbiota, such as increased abundance of Prevotella, Methanobrevibacter, and Ambervirus. Furthermore, there is increasing evidence of the existence of the gut-liver axis, which exchanges signals between the gut and the liver. The portal vein allows the transport of products produced by the microbiota to the liver, and the microbiota is crucial for the homeostasis of the gut-liver axis. Given the accumulating evidence of the pathogenic role of microbiota-derived metabolites in non-alcoholic fatty liver disease, similar mechanisms may apply to more advanced liver diseases.
The research findings also revealed heterogeneous associations of fiber from different food sources. Legumes, vegetables, and fruits are good sources of dietary fiber. Interestingly, fiber from fruits did not show a negative correlation with liver disease mortality, nor did fiber from other sources. Although the potential mechanisms are unclear, excessive fructose has been reported to be associated with insulin resistance, fatty acid production, oxidative stress, and increased fatty liver. Fruits high in fructose may offset the beneficial effects of fiber. Overall, studies suggest that the negative correlation between dietary fiber and liver disease mortality may vary depending on the source of the fiber.
References: Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality.
Note: This article is for informational purposes only and is not intended as medical guidance.
Dietary fiber, Chuangyuan Probiotics, Chuangyuan Biotechnology, Chuangyuan Probiotic Special Diet, Grain fiber, Whole grains
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